Cyclo[n]pyrroles: Size and Site-Specific Binding to G-Quadruplexes
نویسندگان
چکیده
منابع مشابه
Thermodynamic fingerprints of ligand binding to human telomeric G-quadruplexes
Thermodynamic studies of ligand binding to human telomere (ht) DNA quadruplexes, as a rule, neglect the involvement of various ht-DNA conformations in the binding process. Therefore, the thermodynamic driving forces and the mechanisms of ht-DNA G-quadruplex-ligand recognition remain poorly understood. In this work we characterize thermodynamically and structurally binding of netropsin (Net), di...
متن کاملSmall antisense oligonucleotides against G-quadruplexes: specific mRNA translational switches
G-quadruplexes (G4) are intricate RNA structures found throughout the transcriptome. Because they are associated with a variety of biological cellular mechanisms, these fascinating structural motifs are seen as potential therapeutic targets against many diseases. While screening of chemical compounds specific to G4 motifs has yielded interesting results, no single compound successfully discrimi...
متن کاملG-Quadruplexes: From Guanine Gels to Chemotherapeutics
G-quartets are square planar arrangements of four guanine bases, which can form extraordinarily stable stacks when present in nucleic acid sequences. Such G-quadruplex structures were long regarded as an in vitro phenomenon, but the widespread presence of suitable sequences in genomes and the identification of proteins that stabilize, modify or resolve these nucleic acid structures have provide...
متن کاملG-quadruplexes and mRNA localization
G-quadruplexes represent a novelty for molecular biology. Their role inside the cell remains mysterious. We investigate a possible correlation with mRNA localization. In particular, we hypothesize that G-quadruplexes influence fluid dynamics. Localization of mRNA molecules within the cytoplasm recently emerged as a prevalent mechanism for cell polarization, thus underlying developmental process...
متن کاملCellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes.
Guanidino-modified phthalocyanines are evaluated in vitro (polymerase-stop assays and FRET) and in cultured cells as G4-DNA ligands and modulators of gene transcription.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2006
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja0564968